Metabolic diseases

Normal, obese and/or diabetic study subjects.

Colonies of dysmetabolic cynomolgus and marmosets.

Acute, short-infusion or repeated dosing designs.

Normal, obese and/or diabetic study subjects

Colonies of dysmetabolic cynomolgus and marmosets

Acute, short-infusion or repeated dosing designs.

Full clinical chemistry, clinical pathology and clinical toxicology support.

Full clinical chemistry, clinical pathology and clinical toxicology support.

Tissue-specific safety biomarker levels by biosampling, biopsy or microdialysis.

Organ-specific or complete histology and pathology evaluation.

Tissue-specific safety biomarker levels by biosampling, biopsy or microdialysis.

Organ-specific or complete histology and pathology evaluation.

Comprehensive metabolic status testing

Oral or IV glucose tolerance test (GTT)

Meal tolerance test (MTT)

Lipid tolerance test (LTT)

Normal insulin suppression test (NIST)

Graded glucose infusion test (GGT)

Insulin tolerance test (ITT)

Normo-insulinemic or hyper-insulinemic glucose clamps

Comprehensive dysmetabolic biomarkers assays

Glucose, insulin and c-peptide (NHP validated assays)

Lipid panels

Endocrine hormone panels (NHP validated assays)

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